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Home/Faculty/Cell Biology/Xian-Cheng Jiand, PhD
photo of Xian-cheng Jiand

Xian-cheng Jiang, PhD

Distinguished Professor
Department of Cell Biology

Academic Background:
  • Bachelor, Medical Chemistry, Shanghai Medical University ('81)
  • Master, Biochemistry, Shanghai Medical University (鈥�84)
  • Ph.D. Biochemistry, 蘑菇视频 ('89)
  • Post-Doctorate, Columbia University (1990-1993)

 Awards and Honors:

  • 2020
    • SUNY Distinguished Professor
  • 2018
    • The Alfred Stracher Faculty Recognition Award, 蘑菇视频
  • 2015
    • Excellence in Education Award, 蘑菇视频
  • 2010
    • SUNY Chancellor's Award for Excellence in Faculty Service.
  • 2005
    • SUNY Promising Inventor Award
  • 2003
    • SUNY Promising Inventor Award
  • 2002
    • President Research Award, 蘑菇视频
Research Summary (Lipid Metabolism and Metabolic Diseases):

The primary interest of my laboratory is to investigate the effect of lipid metabolism and metabolic diseases, such as atherosclerosis, metabolic syndrome, obesity, and liver steatosis. We are particularly interested in understanding how phospholipid metabolism influences plasma lipoprotein metabolism, cell membrane lipid composition and function, and the development of metabolic diseases. 

We have three on-going specific aspects:

  1. Sphingomyelin biosynthesis. Sphingomyelin is one of the major phospholipids on the cell membrane and in the circulation. The biochemical synthesis of sphingomylin occurs through the actions of serine palmitoyl-CoA transferase (SPT), 3-ketosphinganine reductase, ceramide synthase, dihydroceramide desaturase and sphingomyelin synthase (SMS). We are studying the impact of SPT and SMS activity on lipid metabolism and disease development, using systemic gene knockout or overexpression, and tissue specific gene knockout or overexpression approaches.
  2. Phosphotidycholine (PC) remodeling. PC is the major lipid on cell membrane and all plasma lipoproteins. PCs are first synthesized from glycerol-3-phosphate in the de novo pathway, and undergo maturation in the remodeling pathway, as reported by Lands (Lands鈥� cycle). The remodeling process, which concerns the turnover of about half of the PC molecules, involves the deacylation of PC to lysophosphatidylcholine (lysoPC), followed by reacylation of lysoPC to PC. The deacylation is catalyzed by calcium independent phospholipase A2 (iPLA2) and the reacylation is catalyzed by lysophosphatidylcholine acyltransferase (LPCAT). We are studying LPCAT function, using systemic or tissue specific gene knock out mouse models. 
  3. Phospholipid transfer protein (PLTP). PLTP is an independent risk factor for human coronary artery diseases. In mouse models, it has been shown that systemic PLTP deficiency reduces atherosclerosis,  while its overexpression demonstrates the opposite effect. Therefore, PLTP is considered a promising target for pharmacological intervention in atherosclerosis. However, the mechanisms involved in these reactions are not entirely clear. For better understanding of them, we are evaluating the effect of PLTP on lipoprotein production, using mouse models (systemic or tissue specific knockout) available in our laboratory.
  • Jiang XC, Bruce C.
  • Jiang XC, Francone O, Bruce C, Milne R, Mar J, Walsh A, Tall AR. Increased pre-beta-HDL, apolipoprotein AI and phospholipids in mice expressing the human phospholipids transfer protein and human apoA-I transgenes. J Clin Invest. 1996;96:2373-80
  • Jeong Ts, Schissel SL, Tabas I, Pownall HJ, Tall AR, Jiang XC. J Clin Invest. 1998;101:905-12.
  • Jiang XC, Bruce C, Mar J, Lin M, Ji Y, Francone OL, Tall AR. . J Clin Invest. 1999;103:907-14. 
  • Kawano K, Qin SC, Lin M, Tall AR, Jiang XC.. J Biol Chem. 2000;275:29477-81. 
  • Jiang XC, Paultre F, Pearson TA, Reed RG, Francis CK, Lin M, Berglund L, Tall AR.. Arterioscler Thromb Vasc Biol. 2000;20:2614-8. 
  • Jiang XC, Qin S, Qiao C, Kawano K, Lin M, Skold A, Xiao X, Tall AR. . Nat Med. 2001;7:847-52. Erratum in: Nat Med 2001;7:973.
  • Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum JL, Lagrost L. . J Biol Chem. 2002;277:31850-6 
  • Cao G, Beyer TP, Yang XP, Schmidt RJ, Zhang Y, Bensch WR, Kauffman RF, Gao H, Ryan TP, Liang Y, Eacho PI, Jiang XC. . J Biol Chem. 2002;277:39561-5.
  • Jiang XC, Beyer TP, Li Z, Liu J, Quan W, Schmidt RJ, Zhang Y, Bensch WR, Eacho PI, Cao G. . J Biol Chem. 2003;278:49072-8. 
  • Hojjati MR, Li Z, Zhou H, Tang S, Huan C, Ooi E, Lu S, Jiang XC. . J Biol Chem. 2005;280:10284-9. 
  • Jiang XC, Li Z, Liu R, Yang XP, Pan M, Lagrost L, Fisher EA, Williams KJ . J Biol Chem. 2005;280:18336-40.
  • Liu R, Hojjati MR, Devlin CM, Hansen IH, Jiang XC. . Arterioscler Thromb Vasc Biol. 2007;27:190-6.
  • Liu R, Iqbal J, Yeang C, Wang DQ, Hussain MM, Jiang XC. . Arterioscler Thromb Vasc Biol. 2007;27:2014-21.
  • Hailemariam TK, Huan C, Liu J, Li Z, Roman C, Kalbfeisch M, Bui HH, Peake DA, Kuo MS, Cao G, Wadgaonkar R, Jiang XC. Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation. Arterioscler Thromb Vasc Biol. 2008; 28:1519-26. 
  • Liu J, Zhang H, Li Z, Hailemariam TK, Chakraborty M, Qiu D, Bui HH, Peake DA, Kuo MS, Wadgaonkar R, Cao G, Jiang XC. . Arterioscler Thromb Vasc Biol. 2009; 105:295-303. 
  • Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo M, Cao G, Jiang XC. . Circ. Res. 2009; 105(3):295-303.
  • Li Z, Li Y, Chakraborty M, Fan Y, Bui HH, Peake D.A, Kuo MS, Xiao X, Cao G, Jiang XC. Liver-specific deficiency of serine palmitoyltransferase (SPT) subunit 2 decreases plasma sphingomyelin and apolipoprotein E levels. J. Biol. Chem. 2009; 284(39):27010-9.
  • Fan Y, Shi F, Liu J, Dong J, Bui HH, Peake DA, Kuo MS, Cao G, Jiang XC. .  Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2114-20.
  • Li Z, Zhang H, Liu J, Liang CP, Li Y, Li Y, Teitelman G, Beyer T, Bui HH, Peake DA, Zhang Y, Sanders PE, Kuo MS, Park TS, Cao G,  Jiang XC. Reducing plasma membrane sphingomyelin increases insulin sensitivity. Mol Cell Biol. 2011;31(20):4205-18.
  • Yazdanyar A, Jiang, XC. Liver specific phospholipid transfer protein (PLTP) expression in PLTP null background promotes VLDL production in mice. Hepatology. 2012, 56:576-84.
  • Li Z, Ding, T., Pan, X., Li, Y., Li, R., Sanders, P.E., Kuo, M., Hussain, M.M., Cao, G., and Jiang XC. (2012) . J. Biol. Chem. 2012; 287:20122-31. 
  • Li Z, Fan, Y., Liu, J., Li, Y., Huan, C., Bui, H.H., Kuo, M., Park, T.S., Cao, G., and  Jiang XC. (2012) The effect of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice. Arterioscler. Thromb. Vasc. Biol.2012; 32:1577-84.
  • Chakraborty M, Lou, Huan C, Kuo M, Park T, Cao, G, Jiang XC. Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis. J Clin Invest. 2013;123(5):2332-2339.
  • Yazdanyar A, Quan W, Weijun Jin,  Jiang XC. Liver-specific phospholipid transfer protein (PLTP) deficiency reduces high density lipoprotein (HDL) and non-HDL production. Arterioscler Thromb Vasc Biol. 2013;9:2058-64.
  • Jiang H, Yazdanyar A, Lou B, Chen Y, Zhao X, Li R, Bui H, Kuo MS, Navab M, Qin S, Li Z, Jin W,  Jiang XC. Adipocyte Phospholipid Transfer Protein and Lipoprotein Metabolism. Arterioscler Thromb Vasc Biol. 2015;Feb;35(2):316-22.
  • Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep;21(9):1028-37.
  • Li Z, Jiang H, Ding T, Lou C, Bui HH, Kuo MS, Jiang XC. Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice. Gastroenterology. 2015 Nov;149(6):1519-29.
  • Kabir I, Li Z, Bui HH, Kuo MS, Gao G, Jiang XC. Small intestine but not liver lysophosphatidylcholine acyltransferase 3 (Lpcat3) deficiency has a dominant effect on plasma lipid metabolism. J Biol Chem. 2016 2016 Apr 1;291(14):7651-60
  • Li Z, Kabir I, Jiang H, Zhou H, Libien J, Zeng J, Stanek A, Ou P, Li KR, Zhang S, Bui HH, Kuo MS, Park TS, Kim B, Worgall TS, Huan C, Jiang XC. Liver Serine Palmitoyltransferase (SPT) Activity Deficiency in Early Life Impairs Adherens Junctions and Promotes Tumorigenesis. Hepatology. 2016, Dec. 64(6):2089-2102.
  • Zhao X,Wang Y,Yu Y, Jiang H, Babinska A, Chen WY, He KG, Min XD, Han JJ, Yang CY, Deng K, Xue J, Zhang X, Song GH, Qin SC, Jiang XC. Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. Thrombosis and Haemostasis, 2018;118(12):2086-2097.
  • Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC.  J Biol Chem. 2018;293(47):18328-18336.
  • Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death Dis. 2018 Feb 7;9(2):173.
  • Chen Y, Dong J, Zhang X, Chen X, Wang L, Chen H, Ge J, Jiang XC. Atherosclerosis. 2019;285:147-152.
  • Jiang XC. The Chapter 1: Impact of phospholipid transfer protein on lipoprotein metabolism and cardiovascular diseases. Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease, edited by Xian-Cheng Jiang, Adv Exp Med Biol. 2020;1276:1-13.
  • Jiang XC and Yu Y. The role of phospholipid transfer protein in the development of atherosclerosis. Curr Atheroscler Rep. 2021;23(3):9.

Department Links

Cell Biology