蘑菇视频

Dr. Barone completed graduate school (PhD; 5 years) in Biopsychology-Neuroscience at Syracuse University and was on the faculty there for 4 years as Research Assistant Professor (1973-1982), working on brain connections, neuronal activity and transmitter molecues and behavior). In 1982 he began work as a Drug Discovery Investigator in Gastrointestinal (GI) Pharmacology at (then called) Smith, Kline and French labs in the Philadelphia area of Pennsylvania. Here he moved on to research in Cardiovascular Pharmacology (CV) and focused on CV disease, working on progressing end-organ protective compounds to drugs. His work included developing appropriate animal models of human disease in areas of cardiovascular function and metabolism.

Dr. Barone's primary work became cerebrovascular disease-stroke. He worked as Biology Leader closely with Medicinal Chemister Leaders on many programs/projects/biology disease targets. He left (now called) GlaxoSmithKline, plc (GSK) as Director, In Vivo Biology after collaborating with many GSK groups in the USA, Japan and the UK on a variety of biological targets in disease and developing and using many disease models in drug discovery and repurposing. Thus, after 25 years at GSK, he served as a consultant to other pharmaceutical companies, especially Wyeth-Pfizer Pharmaceuticals.

In 2008, Dr Barone was recruited to SUNY Downstate Medical Center and has worked in his current positions of Professor and Director. His research is focused on cerebrovascular and neurodegenerative disease mechanism and treatments for dementia. In addition to facilitating medical student involvement in scholarly research exposure and training, he has most recently been working in clinical-translational-basic medical science to understand mixed dementia (Alzheimer Disease and related dementias; ADRD) and circulating plasma, cells and extracellular vessicles-exosomes and their cargo, as markers of brain cell and molecular changes in stroke, neurodegeneration and dementia. Thus, his most recent scientific interests at Downstate Health Sciences University are primarily in the disease biology and mechanism-based brain and circulating biomarker changes that can be used for diagnosis, prognosis and monitoring the long-term deficits and recovery of lost cognitive functioning, and to apply these to human medicine.

He is the Founder and President of the Albert Research Institute for White Matter and Cognition, a dementia network facilitating regular scientific communication, collaboration and investigator growth.

Education

• Undergraduate: Syracuse University
• Advanced Degree: Syracuse University

Research Interests

• Cerebrovascular Disease
• Neurodegenerative diseases
• Vascular contributions to dementia
• Alzheimer鈥檚 disease and related dementias
• Biomarkers
• Extracellular vessicles-Exosomes

• Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew A Parsons, Barone FC. . Exp Neurol. 2008 Jul;212(1):53-62.
• Lenhard SC, Strittmatter R, Price WJ, Chandra S, White RF, Barone FC. . Pharmacology. 2008;81(1):1-10.
• Barone FC, . Methods Mol Med. 2005;104:105-84.
• Maguire S, Strittmatter R, Chandra S, Barone FC. . Neurosci Lett. 2004 Jan 16;354(3):229-33.
• Legos JJ, Barone FC. . Curr Opin Investig Drugs. 2003 Jul;4(7):847-58.
• McLaughlin B, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, Aizenman E. . Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):715-20.
• Toomey JR, Valocik RE, Koster PF, Gabriel MA, McVey M, Hart TK, Ohlstein EH, Parsons AA, Barone FC. . Stroke. 2002 Feb;33(2):578-85.
• Read SJ, Parsons AA, Harrison DC, Philpott K, Kabnick K, O' Brien S, Clark S, Brawner M, Bates S, Gloger I, Legos JJ, Barone FC. . J Cereb Blood Flow Metab. 2001 Jul;21(7):755-78.
• Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, Legos JJ, Erhardt JA, Ohlstein EH, Hunter AJ, Harrison DC, Philpott K, Smith BR, Adams JL, Parsons AA. . Med Res Rev. 2001 Mar;21(2):129-45.
• Barone FC, Ohlstein EH, Hunter AJ, Campbell CA, Hadingham SH, Parsons AA, Yang Y, Shohami E. . J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S357-61.
• Currie RW, Ellison JA, White RF, Feuerstein GZ, Wang X, Barone FC. . Brain Res. 2000 Apr 28;863(1-2):169-81.
• Barone FC, Feuerstein GZ. . J Cereb Blood Flow Metab. 1999 Aug;19(8):819-34.
• Velier JJ, Ellison JA, Kikly KK, Spera PA, Barone FC, Feuerstein GZ. . J Neurosci. 1999 Jul 15;19(14):5932-41.
• Barone FC, White RF, Spera PA, Ellison J, Currie RW, Wang X, Feuerstein GZ. . Stroke. 1998 Sep;29(9):1937-50; discussion 1950-1.
• Feuerstein GZ, Wang X, Barone FC. . Neuroimmunomodulation. 1998 May-Aug;5(3-4):143-59.
• Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. . Stroke. 1998 May;29(5):1020-30.
• Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feuerstein GZ. . Stroke. 1997 Jun;28(6):1233-44.
• Barone FC, Feuerstein GZ, White RF. . Neurosci Biobehav Rev. 1997 Jan;21(1):31-44.